Top aptamer papers on cancer — updated daily

Highest-scoring papers · 高分论文

1. AuPt bimetallic nanocatalyst-amplified luminol-dissolved oxygen electrochemiluminescence for interferon-γ immunosensing

   Frontiers in Chemistry · IF 3.8 · 2026-09-03 · 1 citation · score 17.9

   Interferon-γ (IFN-γ) is a pivotal inflammatory cytokine whose abnormal expression is associated with autoimmune disorders, infectious diseases, and cancer. Herein, a signal-off electrochemiluminescence (ECL) immunosensor was developed by integrating catalytic signal amplification with oriented antibody immobilization.…

2. Folic acid-anchored liposomes in cancer therapy: a next-generation nanoplatform for precision drug delivery and tumor targeting

   Journal of biomaterials science. Polymer edition · 2026-09-01 · 2 citations · score 15.5

   Targeted drug delivery (TDD) has emerged as a potential strategy for cancer management by selectively delivering therapeutic agents directly to the targeted site. The current trends in TDD for cancer therapy, focus on the use of various ligands, such as hyaluronic acid, folic acid (FA), carbohydrates, peptides,…

3. Single-Exosome EpCAM Heterogeneity Profiling for Breast Cancer Diagnosis and Progression Monitoring

   Analytical chemistry · IF 6.7 · 2026-09-08 · 0 citations · score 13.7

   Exosomes are nanoscale vesicles that are attractive for liquid biopsy, but most methods deliver ensemble averages and obscure how surface biomarkers vary across individual vesicles. We develop a single-particle impact electrochemistry (SPIE) assay to profile epithelial cell adhesion molecule (EpCAM) on single…

4. Cell-Surface-to-Solution Signal Transduction via a CRISPR/Cas12a-Based Dual-Target Aptamer Sensor for Detecting Urothelial Carcinoma Cells in Urine

   Analytical Chemistry · IF 6.7 · 2026-09-07 · 0 citations · score 13.3

   Abstract Urothelial carcinoma (UC) is a common malignancy of the genitourinary system with high recurrence rates, requiring non-invasive postoperative monitoring. Direct detection of exfoliated UC cells in urine can provide tumor-origin evidence but remains challenging because of low target-cell abundance, complex…

5. Specific detection against PSA by using emission wavelength of carbon dots modulates TiO(2)/In(2)S(3)-based photoelectrochemical aptasensor

   Colloids and surfaces. B, Biointerfaces · 2026-09-01 · 1 citation · score 13.2

   Sensitive and precise detection of prostate-specific antigen (PSA) is essential for the early diagnosis and monitoring of prostate cancer. However, conventional detection methods often suffer from limited sensitivity, poor selectivity, highlighting the need for advanced sensing platforms. Photoelectrochemical (PEC)…

6. Co-profiling of exosomal proteins and microRNAs using single microbead confinement for breast cancer diagnosis

   Biosensors & bioelectronics · IF 10.7 · 2026-09-04 · 0 citations · score 13.1

   Tumor-derived exosomes (TEXs) hold immense promise as biomarkers for cancer diagnosis, but sensitive and accurate identification is hindered by their intrinsic heterogeneity and extreme scarcity. Co-profiling of exosomal protein and microRNA (miRNA) at the single-molecule level may greatly enhance the precision of…

7. Multivariate-Activated DNA Logic Gate for Predicting Responses to Cisplatin-Based Chemotherapy

   Analytical Chemistry · IF 6.7 · 2026-09-06 · 0 citations · score 13.0

   Abstract Cisplatin-based chemotherapy remains an attractive alternative for controlling advanced cancers. However, a subset of cancer patients exhibits resistance to cisplatin. Accurate and early prediction of individual responses to cisplatin treatment is critical to personalized medicine guidance. The development of…

8. Aptamer-Functionalized Liposomes for Targeted Delivery of Anticancer Drugs in Lung Cancer

   Molecules · IF 4.2 · 2026-09-07 · 0 citations · score 12.6

   Aptamer-functionalized liposomes are a promising strategy to improve the selectivity of anticancer therapies. AT11-L2 is a G-quadruplex (G4)-forming aptamer with high affinity for nucleolin (NCL), which is overexpressed at the surface of non-small cell lung cancer (NSCLC) cells. Here, we developed…

9. T cell-anchored ATP-responsive doxorubicin-loaded dual aptamer DNA nanodevice for enhanced solid tumor therapy

   Chemical Engineering Journal · IF 13.4 · 2026-09-01 · 0 citations · score 12.6

10. DNA Tetrahedral Nanoprobes-Based Logic-Gated FRET Sensor for in Situ Analysis of Dual MicroRNAs in Extracellular Vesicles

    Analytical Chemistry · IF 6.7 · 2026-09-04 · 0 citations · score 12.3

    Abstract Conventional analysis of extracellular vesicle (EV)-derived microRNAs relies on vesicle lysis and RNA extraction, which disrupt native vesicular structure and eliminate intravesicular molecular cargoes. Here, we report a rigid DNA tetrahedral nanoprobes-based logic-gated Förster resonance energy transfer…

11. Bifunctional DNA multivalent structure integrating stable capture of urothelial carcinoma cells with CRISPR/Cas12a signal amplification for bladder cancer detection

    Biosensors & bioelectronics · IF 10.7 · 2026-08-15 · 3 citations · score 12.3

    Noninvasive detection of bladder cancer remains challenging due to the limited analytical performance of current urine-based assays under realistic detection conditions. Here, we report a linear programmable DNA nanostructure that integrates multivalent aptamer recognition with CRISPR/Cas12a signal transduction for…

12. Aptamer-mediated portable SERS sensor based on bimetallic magnetic nanotubes for internal standard-calibrated detection of multi-target disease markers

    Biosensors & bioelectronics · IF 10.7 · 2026-09-01 · 0 citations · score 12.1

    Accurate early screening for hepatocellular carcinoma (HCC) requires multi-target detection methods with high sensitivity and strong anti-interference capability. In this study, we developed an aptamer-mediated SERS sensing method based on bimetallic magnetic nanotubes for the simultaneous detection of HCC markers…

13. In-Capillary Integrated CE-LIF Platform with Bioinformatics-Guided Exosome Capture and Isothermal Amplification for Ultrasensitive Multiplexed Detection of HCC-Derived Exosomal MicroRNAs

    Analytical Chemistry · IF 6.7 · 2026-09-03 · 0 citations · score 12.0

    Abstract Exosomal microRNAs (Exo-miRNAs) are promising liquid-biopsy biomarkers for noninvasive cancer detection; yet due to their short length, low abundance, and high sequence homology, the determination of Exo-miRNAs suffers from insufficient sensitivity, limited multiplexing, and operational complexity, impeding…

14. Precise Mutation Detection in Low-Abundance Tumor-Derived Extracellular Vesicles via Microfluidic Immunomagnetic Reversible Affinity Capture

    Analytical Chemistry · IF 6.7 · 2026-09-02 · 0 citations · score 11.7

    Abstract Molecular diagnostic technologies based on liquid biopsy are increasingly vital for clinical tumor molecular profiling. Compared to highly fragmented and easily degradable cell-free DNA (cfDNA), extracellular vesicles (EVs) offer distinct advantages by protecting nucleic acids from degradation. Enrichment of…

15. Catalytic BiFeO3/g-C3N4 Heterojunction Nanosheets Coupled with DNAzyme/Low-Leakage Sequential DNA Circuit for Ultrasensitive Electrochemical Aptamer-Based Detection of Colorectal Cancer Exosomes

    Analytical chemistry · IF 6.7 · 2026-09-01 · 0 citations · score 11.3

    Tumor-derived exosomes are promising circulating biomarkers for early colorectal cancer (CRC) diagnosis, yet their low abundance and the complexity of biological fluids demand sensing strategies with both stringent specificity and amplified signal output. Here, we report an ultrasensitive electrochemical aptasensor…

16. CHAI-sEV: A Programmable Hairpin-Driven Cas9 Platform with AI Integration for Dual-Protein Profiling and Intelligent Classification of Tumor-Derived Small Extracellular Vesicles

    Analytical Chemistry · IF 6.7 · 2026-09-01 · 0 citations · score 11.3

    Abstract Multiplexed protein profiling of tumor-derived small extracellular vesicles (TsEVs) requires signal-conversion strategies that are sensitive, low-background, and orthogonal. Collateral-cleavage CRISPR assays based on Cas12a or Cas13a provide efficient amplification but can compromise single-pot multitarget…

17. Conducting Polymer–Nanomaterial Hybrids for Cancer Diagnostics

    Biosensors · IF 5.4 · 2026-09-01 · 0 citations · score 11.0

    Cancer continues to pose a major global burden because of the high incidence and mortality, underscoring the urgent need for innovative and highly sensitive diagnostic technologies. Conducting polymer–nanomaterial (CP–NM) hybrid biosensors have become promising platforms for cancer biomarker detection, integrating the…

18. Oxygen vacancies-induced dual-interface modulation for TiO(2)/BiOI-based photoelectrochemical biosensor of urinary cancer markers

    Biosensors & bioelectronics · IF 10.7 · 2026-08-28 · 0 citations · score 10.8

    Non-invasive urine-based cancer biomarker detection holds significant clinical value in cancer screening, treatment efficacy monitoring, recurrence warning, and auxiliary diagnosis. To address the issues of poor sensitivity and selectivity in photoelectrochemical (PEC) biosensing for the detection of cancer biomarkers…

19. An integrated protein detection platform based on “lock-and-cage” sensors and digital microfluidics

    Biosensors and Bioelectronics · IF 10.7 · 2026-08-27 · 0 citations · score 10.5

    Data-driven protein engineering has enabled biosensors that directly couple molecular recognition with measurable signal outputs, providing a powerful strategy for rapid protein analysis. However, their integration into automated and portable analytical systems remains limited. Here, we developed an integrated…

20. Flexible 3D-Printed Polydimethylsiloxane Microdevice with a Ternary Heterojunction-Engineered Photoanode for Sensitive Photoelectrochemical Detection of Tumor Necrosis Factor-α in Sweat

    ACS sensors · IF 8.2 · 2026-08-28 · 0 citations · score 10.3

    The detection of low-abundance biomarkers in sweat with high sensitivity is essential for wearable health monitoring applications. However, the performance of conventional photoelectrochemical (PEC) sensors is constrained by their rigid substrates, inefficient charge separation, and limited miniaturization capability.…