Aptamer 学术简报 — cancer — 2026-09-08

自动生成 by RBTX Aptamer Tracker v0.1。 子主题 cancer：近 14 天 47 篇命中（aptamer 池 231 篇）。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [14.0] Specific detection against PSA by using emission wavelength of carbon dots modulates TiO(2)/In(2)S(3)-based photoelectrochemical aptasensor.

Sensitive and precise detection of prostate-specific antigen (PSA) is essential for the early diagnosis and monitoring of prostate cancer. However, conventional detection methods often suffer from limited sensitivity, poor selectivity, highlighting the need for advanced sensing platforms. Photoelectrochemical (PEC) biosensing achieve for PSA acc...

#2 [13.5] Co-profiling of exosomal proteins and microRNAs using single microbead confinement for breast cancer diagnosis.

Tumor-derived exosomes (TEXs) hold immense promise as biomarkers for cancer diagnosis, but sensitive and accurate identification is hindered by their intrinsic heterogeneity and extreme scarcity. Co-profiling of exosomal protein and microRNA (miRNA) at the single-molecule level may greatly enhance the precision of cancer diagnosis and prognosis....

#3 [13.3] Multivariate-Activated DNA Logic Gate for Predicting Responses to Cisplatin-Based Chemotherapy

Abstract Cisplatin-based chemotherapy remains an attractive alternative for controlling advanced cancers. However, a subset of cancer patients exhibits resistance to cisplatin. Accurate and early prediction of individual responses to cisplatin treatment is critical to personalized medicine guidance. The development of an effective method to pred...

#4 [12.9] T cell-anchored ATP-responsive doxorubicin-loaded dual aptamer DNA nanodevice for enhanced solid tumor therapy

#5 [12.7] DNA Tetrahedral Nanoprobes-Based Logic-Gated FRET Sensor for in Situ Analysis of Dual MicroRNAs in Extracellular Vesicles

Abstract Conventional analysis of extracellular vesicle (EV)-derived microRNAs relies on vesicle lysis and RNA extraction, which disrupt native vesicular structure and eliminate intravesicular molecular cargoes. Here, we report a rigid DNA tetrahedral nanoprobes-based logic-gated Förster resonance energy transfer (FRET) platform for in situ, am...

#6 [12.5] Aptamer-mediated portable SERS sensor based on bimetallic magnetic nanotubes for internal standard-calibrated detection of multi-target disease markers.

Accurate early screening for hepatocellular carcinoma (HCC) requires multi-target detection methods with high sensitivity and strong anti-interference capability. In this study, we developed an aptamer-mediated SERS sensing method based on bimetallic magnetic nanotubes for the simultaneous detection of HCC markers alpha-fetoprotein (AFP) and Gol...

#7 [12.3] In-Capillary Integrated CE-LIF Platform with Bioinformatics-Guided Exosome Capture and Isothermal Amplification for Ultrasensitive Multiplexed Detection of HCC-Derived Exosomal MicroRNAs

Abstract Exosomal microRNAs (Exo-miRNAs) are promising liquid-biopsy biomarkers for noninvasive cancer detection; yet due to their short length, low abundance, and high sequence homology, the determination of Exo-miRNAs suffers from insufficient sensitivity, limited multiplexing, and operational complexity, impeding their high-throughput clinica...

#8 [12.0] Precise Mutation Detection in Low-Abundance Tumor-Derived Extracellular Vesicles via Microfluidic Immunomagnetic Reversible Affinity Capture

Abstract Molecular diagnostic technologies based on liquid biopsy are increasingly vital for clinical tumor molecular profiling. Compared to highly fragmented and easily degradable cell-free DNA (cfDNA), extracellular vesicles (EVs) offer distinct advantages by protecting nucleic acids from degradation. Enrichment of tumor-derived EVs using spec...

#9 [11.7] Catalytic BiFeO3/g-C3N4 Heterojunction Nanosheets Coupled with DNAzyme/Low-Leakage Sequential DNA Circuit for Ultrasensitive Electrochemical Aptamer-Based Detection of Colorectal Cancer Exosomes.

Tumor-derived exosomes are promising circulating biomarkers for early colorectal cancer (CRC) diagnosis, yet their low abundance and the complexity of biological fluids demand sensing strategies with both stringent specificity and amplified signal output. Here, we report an ultrasensitive electrochemical aptasensor for SW620 cell-derived exosome...

#10 [11.7] CHAI-sEV: A Programmable Hairpin-Driven Cas9 Platform with AI Integration for Dual-Protein Profiling and Intelligent Classification of Tumor-Derived Small Extracellular Vesicles

Abstract Multiplexed protein profiling of tumor-derived small extracellular vesicles (TsEVs) requires signal-conversion strategies that are sensitive, low-background, and orthogonal. Collateral-cleavage CRISPR assays based on Cas12a or Cas13a provide efficient amplification but can compromise single-pot multitarget detection, whereas the sequenc...

Methodology