Top aptamer papers on biosensors — updated daily

Highest-scoring papers · 高分论文

1. Selection and validation of novel DNA aptamer panel co-specific to Plasmodium falciparum and Plasmodium ovale lactate dehydrogenase

   Molecular therapy. Nucleic acids · IF 8.8 · 2026-09-08 · 1 citation · score 27.2

   Malaria remains a major global health concern. The development of point-of-care diagnostic aptasensors could improve malaria detection, patient management, and eradication efforts. We selected and validated single-stranded DNA aptamers against Plasmodium falciparum lactate dehydrogenase (Pf-LDH), using systematic…

2. Self-powered photoelectrochemical aptasensor based on CHA-triggered G-quadruplex/hemin cascade for homogeneous detection of ochratoxin A in a separated-coupling electrolysis system

   Biosensors & bioelectronics · IF 10.7 · 2026-09-01 · 5 citations · score 23.5

   To address the challenge of electroactive interferences derived from complex food matrices during homogeneous photoelectrochemical (PEC) biosensing, a "separated-coupling" electrolysis platform was rationally engineered for the ultrasensitive detection of ochratoxin A (OTA). Based on the analysis of the conduction…

3. A novel triple-mode sensor utilizing trimetallic derived fluorescent carbon dots nanozyme for tetracycline determination

   Biosensors & bioelectronics · IF 10.7 · 2026-09-01 · 3 citations · score 21.7

   Tetracycline (TC) is notoriously resistant to degradation in natural environments, which contributes to its prolonged persistence and widespread contamination. Improper or excessive use of TC can lead to multifaceted hazards. In this study, we developed a trimetallic-doped carbon dots (Fe,Cu,Ce-CDs)-based composite…

4. Electrochemically covalent lock stabilizes aptamer conformation and strengthens its sensing performance for PFOA

   Analytica chimica acta · IF 5.4 · 2026-09-01 · 2 citations · score 19.1

   PER: and polyfluoroalkyl substances (PFAS) are widely detected emerging pollutants, yet their accurate identification in complex water remains a major challenge. Herein, we developed an innovative aptamer (Apt) -based electrochemical molecularly imprinted polymer (MIP) sensor for high-sensitivity detection of…

5. AuPt bimetallic nanocatalyst-amplified luminol-dissolved oxygen electrochemiluminescence for interferon-γ immunosensing

   Frontiers in Chemistry · IF 3.8 · 2026-09-03 · 1 citation · score 17.9

   Interferon-γ (IFN-γ) is a pivotal inflammatory cytokine whose abnormal expression is associated with autoimmune disorders, infectious diseases, and cancer. Herein, a signal-off electrochemiluminescence (ECL) immunosensor was developed by integrating catalytic signal amplification with oriented antibody immobilization.…

6. From rational engineering of a broad-spectrum aptamer to multi-residue screening: A fluorescent aptasensor for multiplexed sulfonamides

   Talanta · IF 6.1 · 2026-09-01 · 1 citation · score 17.1

   The increasing prevalence of multiple antibiotic residues in animal-derived foods presents significant challenges for monitoring efforts. Broad-spectrum aptamers offer great promise for enabling multiplex detection of various antibiotic residues. However, aptamers directly screened for this purpose often exhibit low…

7. Nanomaterial-enabled CRISPR-Cas biosensing for non-nucleic acid targets: Strategies, mechanisms, and applications

   Talanta · IF 6.1 · 2026-09-01 · 1 citation · score 17.1

   Nanomaterial-assisted CRISPR-Cas biosensing has transcended nucleic acid detection, emerging as a prominent paradigm for the ultrasensitive analysis of non-nucleic acid targets. This review systematically elucidates recent advances by proposing a novel three-dimensional framework encompassing transduction efficiency,…

8. A bimetallic metal-organic framework-based aptasensor for dual-mode colorimetric and fluorescent detection of Fumonisin B(1)

   Talanta · IF 6.1 · 2026-09-01 · 1 citation · score 17.1

   Fumonisin B1 (FB1) is a secondary metabolite produced by Fusarium species and is considered one of the most dangerous mycotoxins. It is widely present in maize and other agricultural commodities, posing severe threats to human health and animal husbandry. Consequently, the development of a convenient and rapid…

9. Miniaturization of Aptasensors in Organic Electrochemical Transistors for Sensitivity Enhancement

   Analytical chemistry · IF 6.7 · 2026-09-08 · 0 citations · score 13.7

   Aptasensors have received intense interest because of their selectivity and synthetic flexibility. Aptamer bioreceptors were recently combined with organic electrochemical transistors (OECTs) to increase the signal strength. Although promising, a lack of fundamental understanding of the scaling of these OECT-based…

10. AquaQuanta Portable Multiplex Photonic Aptasensor Based on Cholesteric Liquid Crystal Network for Toxins Detection

    Analytical chemistry · IF 6.7 · 2026-09-08 · 0 citations · score 13.7

    The increasing frequency of harmful algal blooms (HABs) driven by climate change has raised concerns regarding the detection of toxins such as okadaic acid (OA), cylindrospermopsin (CY), microcystins (MC), and anatoxin (ANA) in environmental samples. These toxins pose significant risks to human health, ecosystem, and…

11. A 3D Multiarm PEG/Aptamer-Engineered Interface with Superior Antifouling and Selectivity for Trace Aflatoxin Profiling

    Analytical chemistry · IF 6.7 · 2026-09-08 · 0 citations · score 13.7

    It is challenging to develop a highly selective and antifouling mass spectrometry (MS) ionization interface for the rapid and sensitive detection of trace analytes in complex matrices, such as aflatoxins (AFs) in Traditional Chinese Medicines (TCMs) and milk. In this study, a bifunctional 8-arm PEG derivative…

12. Iodine-Vacancy BiOI Nanosheets-Embedded on Bi2O3 Electrospun Heterojunction for Label-Free Interleukin-6 Photoelectrochemical Aptasensor with High Signal-to-Noise Ratio

    Analytical chemistry · IF 6.7 · 2026-09-08 · 0 citations · score 13.7

    Lower-background photoelectrochemical (PEC) bioanalysis is crucial for high-sensitivity biomolecule detection and early clinical disease screening by effectively eliminating matrix interference and reducing the background photocurrent noise. In this work, a novel, simple, label-free split-type PEC aptasensor was…

13. Electrochemical DNA Biosensors Formed from Self-Assembled Monolayers of Thiolated DNA and Mercaptohexanol: What We Know About This Interface

    ACS sensors · IF 8.2 · 2026-09-06 · 0 citations · score 13.3

    Alkanethiol self-assembled monolayers have dominated methods for forming nucleic acid-modified functional interfaces on gold nanoparticles and electrodes due to the ease and spontaneous nature of gold-sulfur bond formation. In particular, an interface composed of DNA modified with a thiol-terminated, 6-carbon linker…

14. Cell-Surface-to-Solution Signal Transduction via a CRISPR/Cas12a-Based Dual-Target Aptamer Sensor for Detecting Urothelial Carcinoma Cells in Urine

    Analytical Chemistry · IF 6.7 · 2026-09-07 · 0 citations · score 13.3

    Abstract Urothelial carcinoma (UC) is a common malignancy of the genitourinary system with high recurrence rates, requiring non-invasive postoperative monitoring. Direct detection of exfoliated UC cells in urine can provide tumor-origin evidence but remains challenging because of low target-cell abundance, complex…

15. Significantly Liberating Peroxidase-Mimicking Activity from pH Constraints and Fluorescence Enhancement by Surface Modulation of Copper Nanoclusters: Dual-Modal Sensitive Detection of Antibiotics Kanamycin

    Analytical Chemistry · IF 6.7 · 2026-09-07 · 0 citations · score 13.3

    Abstract Nanozymes have great potential as substitutes for natural enzymes. However, most nanozymes experience unsatisfactory catalytic activity and narrow optimal pH conditions, which greatly limit their wide applications. Herein, we report that copper nanoclusters (Cu NCs) exhibit peroxidase (POD) activity and red…

16. Multi-screening of beta-lactam antibiotics in milk based on Fe(3)O(4)@phage/bacteria system and aggregation induced emission luminogen

    Analytica chimica acta · IF 5.4 · 2026-09-08 · 0 citations · score 13.3

    BACKGROUND: For the previous rapid screening methods, antibody, molecularly imprinted polymer, aptamer and receptor are the usually used recognition reagents. It is well known that there are many antibiotic receptors on bacterial surface, so in theory the whole bacterium can be used as recognition reagent for…

17. Specific detection against PSA by using emission wavelength of carbon dots modulates TiO(2)/In(2)S(3)-based photoelectrochemical aptasensor

    Colloids and surfaces. B, Biointerfaces · 2026-09-01 · 1 citation · score 13.2

    Sensitive and precise detection of prostate-specific antigen (PSA) is essential for the early diagnosis and monitoring of prostate cancer. However, conventional detection methods often suffer from limited sensitivity, poor selectivity, highlighting the need for advanced sensing platforms. Photoelectrochemical (PEC)…

18. Matrix‐Activated Aptamer Sensors for Human Serum Analysis

    Angewandte Chemie · IF 16.1 · 2026-09-02 · 0 citations · score 13.2

    ABSTRACT Owing to their ease of operation, solution‐phase fluorescent sensors hold a crucial position among aptamer‐based detection tools. However, their performance is regularly compromised when exposed to increasing levels of blood fluids, such as human serum, which limits their potential in clinical settings. Here,…

19. Matrix-Activated Aptamer Sensors for Human Serum Analysis

    Angewandte Chemie (International ed. in English) · IF 16.1 · 2026-09-02 · 0 citations · score 13.2

    Owing to their ease of operation, solution-phase fluorescent sensors hold a crucial position among aptamer-based detection tools. However, their performance is regularly compromised when exposed to increasing levels of blood fluids, such as human serum, which limits their potential in clinical settings. Here, we…

20. Co-profiling of exosomal proteins and microRNAs using single microbead confinement for breast cancer diagnosis

    Biosensors & bioelectronics · IF 10.7 · 2026-09-04 · 0 citations · score 13.1

    Tumor-derived exosomes (TEXs) hold immense promise as biomarkers for cancer diagnosis, but sensitive and accurate identification is hindered by their intrinsic heterogeneity and extreme scarcity. Co-profiling of exosomal protein and microRNA (miRNA) at the single-molecule level may greatly enhance the precision of…