Top aptamer papers on infectious disease — updated daily
The 20 highest-scoring aptamer papers on infectious disease, ranked by the formula below and rebuilt every day. Drawn from 98 matching papers (out of 2089 in the aptamer corpus) published 2026-05-12 to 2026-09-08 across 75 journals.
按下方公式排序的 infectious disease 方向高分适配体论文，每日重建。取自语料中命中该主题的 98 篇（全库 2089 篇），发表于 2026-05-12 至 2026-09-08，涉及 75 个期刊。
Highest-scoring papers · 高分论文
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An interface-engineered signal-on electrochemical aptasensor for H5N2 avian influenza virus detection
Outbreaks of avian influenza virus (AIV) cause substantial economic losses in the poultry industry, highlighting the need for sensitive, reliable and field-adaptable detection platforms. In this study, we report a signal-on electrochemical aptasensor for avian influenza virus H5N2(K08-404) by translating a previously…
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A Rationally Designed Split Lettuce Aptamer Based on Large-Scale Mutational Analysis
Split-aptamer biosensors offer exceptionally low background by assembling only in the presence of a target analyte; however, their performance is frequently limited by the lack of robust design rules for selecting effective split sites. Existing approaches largely rely on heuristic, structure-based assumptions that…
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Multifunctional CMC–Nanographene Oxide Hydrogels Couple Fluorophore-Free Cancer Cell Imaging with Antioxidant and Antimicrobial Activity
Background: The development of sustainable biomaterials that combine imaging capability with complementary biological functions without relying on incorporated drugs or exogenous fluorophores represents an attractive strategy for multifunctional biomedical platforms. Methods: Here, carboxymethyl cellulose (CMC)…
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DNA aptamers to interfere with HasA, the hemophore of the heme assimilation system in Pseudomonas aeruginosa, as a potential antimicrobial strategy
Pseudomonas aeruginosa relies on heme acquisition to sustain growth and virulence in the iron-limited environment of the host, particularly in the acidic airways of patients with cystic fibrosis where antibiotic efficacy is markedly reduced. The Has heme assimilation system is initiated by the secreted hemophore HasA,…
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Identification of a SARS-CoV-2 Spike RNA-Cleaving DNAzyme and Optimization of Its AS1411 Chimera
Sequence-specific cleavage of viral RNA by deoxyribozymes offers a direct approach for suppressing viral gene expression, although limited cellular accessibility remains a major barrier to their functional application. In this study, a panel of eight deoxyribozymes representing different catalytic motifs and target…
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Target, silence, replace: a review on RNA-based drugs in modern medicine
RNA therapies have evolved into a revolutionary approach in contemporary medicine for treating various diseases by directly targeting RNA molecules engaged in disease pathogenesis. These therapeutic agents regulate biological processes through diverse mechanisms, including modulation of RNA function and gene…
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High-ThroughputOn-Chip Screening Enables Rapid Adaptationof DNA Aptamers to SARS-CoV-2 Evolution
Abstract Rapid pathogen evolution threatens public health by eroding the effectiveness of vaccines, therapeutics, and diagnostic tools. Although spike-protein-targeting monoclonal antibodies (mAbs) were developed within 10–12 months of the initial outbreak to serve as key theranostic agents, their redesign has…
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Chimeric ascorbic acid phosphate-releasing nucleotide probes for isothermal signal-amplified protein detection
Protein detection is essential for disease diagnosis and biomarker analysis but often relies on antibodies and sophisticated instrumentation. Here, we report a signal-amplified protein detection strategy based on chimeric ascorbic acid-2-phosphate (AAP)-releasing nucleotide probes and strand displacement amplification…
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Advancing Tuberculosis Antigen Detection by Selecting Sandwich-Compatible Aptamers Against the Mycobacterium tuberculosis ESAT-6/CFP-10 Heterodimer Using Library-Immobilized Strategies
Abstract Tuberculosis (TB) represents the world’s leading infectious disease killer, surpassing COVID-19. Despite being preventable and curable, a substantial proportion of cases remain undiagnosed or unreported, sustaining transmission. The detection of antigens such as the Mycobacterium tuberculosis ESAT-6/CFP-10…
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Surface-confined CRISPR-Cas12a biosensor with metal-enhanced fluorescence for rapid and ultrasensitive detection of SARS-CoV-2 nucleocapsid protein
CRISPR-Cas12a integrated with nanomaterials has formulated powerful biosensors for viral protein detection, addressing the urgent need for point-of-care diagnostics. However, existing platforms are hindered by either multi-step separation procedures or insufficient signal amplification, limiting their sensitivity and…
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Aptamer modified NPA hollow nanozymes with intrinsic peroxidase-like activity for colorimetric sensing of H1N1
A colorimetric sensor based on aptamer-functionalized nanozyme probes was successfully developed for the sensitive and specific detection of influenza A (H1N1) virus. In this study, trimetallic nickel-palladium-gold hollow nanozymes (NPA) with excellent peroxidase (POD)-like activity were used as catalytic probes.…
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From host response to genomic targets: electrochemical biosensing of tuberculosis biomarkers
Tuberculosis (TB) remains one of the leading causes of death from a single infectious agent worldwide, with timely diagnosis continuing to be a major challenge, particularly in resource-limited settings. Conventional TB diagnostic methods are limited by low sensitivity, long turnaround times, and an inability to…
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Single-Particle Tracking and Positional Phenotyping Reveal Variant-Specific Early Checkpoints in SARS-CoV-2 Cell Entry
Bulk assays of SARS-CoV-2 entry obscure individual virions and conflate binding with internalization. We developed a quantitative single-particle imaging assay that classifies fluorescent virus-like particles (VLPs) as surface, crossing, or internal on HEK293T-ACE2 cells, separating binding from internalization.…
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Strategies for biofilm disruption: Mechanisms, polymeric networks, mixed infections, and emerging biomaterials
Biofilms represent the predominant microbial lifestyle in clinical and environmental settings, where the extracellular polymeric substance (EPS) matrix provides structural integrity, metabolic cooperation, and pronounced antimicrobial tolerance. This matrix forms a dynamic macromolecular network of polysaccharides,…
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Scalable and sustainable manufacturing of functional DNA nanoassemblies via self-folding circular single-stranded DNA
Functional DNA nanoassemblies (fDns) hold promise for biomedical and translational applications, but broader deployment is limited by manufacturing barriers that constrain scalability, reproducibility, and stability. Current biosynthetic approaches rely heavily on downstream enzymatic processing and purification,…
- Triplex-helix molecular beacon-enabled CRISPR/Cas12a biosensor for sensitive detection of SARS-CoV-2
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Functionalized carbon nanotube-assisted dual-mode CRISPR/Cas12a detection of hepatitis C virus via catalytic assembly circuit-driven Y-shaped dsDNA activators
Hepatitis C virus (HCV) is a major etiological agent of liver diseases and remains a serious global health threat. Herein, we report a dual-modal HCV biosensing platform for ultrasensitive HCV RNA detection by integrating near-infrared fluorescence and colorimetric readouts. In this system, the presence of HCV RNA…
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A novel nanosensor for in situ detection of EV-miR-107 enables noninvasive tuberculosis diagnosis and treatment monitoring
Tuberculosis (TB) remains a leading cause of infectious death globally, creating an urgent need for rapid and non-invasive diagnostics. Extracellular vesicles (EVs) have emerged as promising carriers of disease-specific microRNAs with biomarker potential. This study identifies EV-miR-107 as a candidate host-response…
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Aptamer-Loaded Cubosome Lipid Nanoparticles for the Treatment of Tuberculosis
Tuberculosis (TB), particularly multidrug-resistant TB (MDR-TB), remains a critical global health challenge, necessitating innovative approaches to enhance treatment efficacy and overcome resistance mechanisms. Aptamers, short, single-stranded nucleic acids, are under active investigation for both diagnosis and…
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Ag85A-PEGylated Propolis Nanoparticles Exhibit Intracellular Antimycobacterial and Host-Protective Activities Against Mycobacterium tuberculosis
Tuberculosis (TB), caused by the intracellular pathogen Mycobacterium tuberculosis (Mtb), remains a major global health challenge. The prolonged duration of treatment and the emergence of multidrug-resistant strains have highlighted the need for alternative therapeutic strategies. This study investigated the…
How this list is built · 这份榜单怎么来的
Sources. PubMed, OpenAlex and bioRxiv are polled daily for aptamer-related publications; records are de-duplicated by DOI.
Topic filter. A paper enters this list when its title or abstract matches any of: SARS-CoV-2, COVID*, influenza, HIV, HBV, HCV, tuberculosis, Mycobacterium, Ebola, Zika, Dengue, bacterial infect*, viral infect*, pathogen detect*, antimicrobial, antibiotic resist* (SQLite FTS5, case-insensitive, * is a prefix wildcard). A paper can belong to several topics.
Ranking. composite = 0.45×log(IF) + 0.35×log(citation velocity) + 0.10×social + 0.10×recency, scaled to 100. Citation velocity is citations per day since publication, so a recent paper accruing citations quickly can outrank an older one with a larger total. The recency term decays linearly to zero at 30 days, so anything older than a month is ranked on impact and citation velocity alone — this list therefore tilts towards recent work by design.
What this is not. The ranking is computed from metadata — journal impact factor, citation counts, recency — not from reading the papers. It is a triage aid for deciding what to read, not a quality judgement or a substitute for a systematic review. Impact factor is missing for some venues (preprints in particular) and those papers score lower than their content may deserve.
这份榜单由元数据算出——期刊影响因子、引用数、时效性——而不是通过阅读论文得到。它是决定「先读哪篇」的分诊工具，不是质量判断，也不能替代系统综述。部分来源（尤其预印本）没有影响因子，其得分会低于内容应得的水平。
Where these papers appear · 语料期刊分布
| Journal | Papers | IF |
|---|---|---|
| bioRxiv (Cold Spring Harbor Laboratory) | 7 | — |
| ACS sensors | 4 | 8.2 |
| Zenodo (CERN European Organization for Nuclear Research) | 4 | — |
| ACS Sensors | 3 | 8.2 |
| Biosensors & bioelectronics | 2 | 10.7 |
| eLife | 2 | 6.4 |
| International journal of molecular sciences | 2 | 5.0 |
| Analytical methods : advancing methods and applications | 2 | 3.0 |
Daily archive · 每日归档（30 期）
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