Top aptamer papers on neurodegeneration — updated daily
The 20 highest-scoring aptamer papers on neurodegeneration, ranked by the formula below and rebuilt every day. Drawn from 63 matching papers (out of 2068 in the aptamer corpus) published 2026-05-13 to 2026-09-07 across 44 journals.
按下方公式排序的 neurodegeneration 方向高分适配体论文，每日重建。取自语料中命中该主题的 63 篇（全库 2068 篇），发表于 2026-05-13 至 2026-09-07，涉及 44 个期刊。
Highest-scoring papers · 高分论文
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High-Performance Screen-Printed OECT-Inspired with Encased Cassette Based on PEDOT:GO for Sensitive and Specific Electrochemical Aptasensing of Aβ-42 in Management of Alzheimer's Disease
Recently, substantial interest has emerged in developing point-of-care diagnostic devices for Alzheimer's disease (AD), a progressive neurodegenerative disorder characterized by the accumulation of beta-amyloid (Aβ1-42) peptides that act as critical biomarkers for early detection. In response to the growing demand for…
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A signal-locked clamped hybridization chain reaction nanoamplifier for rapid and highly sensitive analysis of Aβ42
Amyloid-beta 42 (Aβ42) is a core biomarker associated with Alzheimer's disease (AD), but accurate quantification of low-abundance plasma Aβ42 remains challenging because of matrix interference, limited assay sensitivity, and time-consuming procedures in conventional methods. Herein, we developed an enzyme-free…
- Photoelectrochemical highly efficient detection of β-amyloid 1-42 based on in-situ grown donor-acceptor covalent organic frameworks combined with dual-aptamer sandwich amplification strategy
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Antibodies and aptamers as affinity ligands for exosome isolation, detection, and targeted delivery: A review
Exosomes, key mediators of intercellular communication, are emerging as promising tools for disease diagnosis and therapy. Realizing this potential depends on technologies that can isolate, detect, and deliver exosomes with high specificity and efficiency. Affinity-based strategies that exploit the molecular…
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Steric hindrance effect synergizing hole-trapping technique: High-Stability and high-accuracy Si/CdS n-n heterojunction photoelectrochemical biosensing of amyloid-β42
Due to rapid carrier recombination and photodegradation, cadmium sulfide (CdS), an n-type semiconductor photosensitive material, has a low utilization efficiency that restricts its use in biosensing. A synergistic hole-trapping approach utilizing steric hindrance effects is proposed in this paper. First, chemical bath…
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Aptamer-Based Platforms for Human Aging Biomarkers: Multiplexed Proteomics, Biosensors and Translational Perspectives
Aptamer-based multiplexed proteomic platforms, especially the SOMAmer-based SomaScan assay, are widely used for large-scale discovery of circulating biomarkers relevant to human aging. This review summarizes 42 original research articles published from 2020 through 2026 in which aptamers or aptamer-derived biosensors…
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A bioelectronic interface for continuous neuroinflammation monitoring and neuromodulation in Parkinson's disease model
Neuroinflammation is increasingly recognized as a critical driver in the onset and progression of Parkinson's disease (PD), yet technologies capable of continuously tracking neuroinflammatory dynamics in vivo remain limited. Here, we report an implantable bioelectronic interface that integrates multiplexed aptamer…
- Author Correction: Circular RNA aptamers targeting neuroinflammation ameliorate Alzheimer disease phenotypes in mouse models
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Label-free electrochemical aptasensor for sensitive and selective recognition of N(6)-Methyladenosine: Applicability in human urine
The specific and accurate detection of ultra-low levels of N6-methyladenosine (m6A) in biological samples holds great potential in the clinical diagnosis of various cancer types and neurodegenerative diseases. In this study, a cost-effective, label-free electrochemical aptasensor was developed by self-assembling a…
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Development of an RNA aptamer as a therapeutic agent for synucleinopathies
The aggregation of α-synuclein (αSyn), a 140-mer protein, has been implicated in the pathogenesis of Parkinson's disease, multiple system atrophy, and dementia with Lewy bodies. KTKEGV pseudo-repeats (KRs) in the sequence of αSyn are key mediators of its prion-like propagation and neurodegeneration. Despite the…
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Aptamer-Targeted PrPC Drives Colorectal Cancer Metastasis via a LYN-STAT3 Complex and Enables Liquid Biopsy Detection
Colorectal cancer (CRC) poses a significant global health challenge, highlighting the need for better diagnostic tools and molecular targets. Compared to traditional antibodies, aptamers, which are single-stranded oligonucleotides with high affinity and low immunogenicity, offer an ideal platform for discovering novel…
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Radical‐Mediated In Situ Fluorescence Dye Deposition: A Simple Interfacial Signal Amplification Reaction for Ultrasensitive Immunoassay on Barcode Beads
Ultrasensitive detection of low-abundance protein biomarkers is crucial for early disease diagnosis but remains challenging for the conventional barcode beads-based suspension chip platform due to the limited detection sensitivity. Here, we report a conceptually novel reaction termed "radical-mediated in situ…
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Screening molecular recognition element-based SWCNT optical sensors for the inflammatory cytokine TNF-α
TNF-α (Tumor Necrosis Factor) is a proinflammatory cytokine that amplifies inflammatory response and promotes leukocyte recruitment. TNF-α is primarily produced by activated macrophages, among others, in response to infection, inflammation, or tissue damage. Given its central role in normal and abnormal immune…
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A label-free electrochemical aptasensor enables ultrasensitive and specific detection of neurofilament light
Plasma neurofilament light chain (NfL) has been identified as a promising early-stage Alzheimer's disease (AD) biomarker, reflecting neuroaxonal degeneration at preclinical stages. However, its extremely low concentration in blood presents a major analytical challenge. Although single-molecule array (Simoa) assays…
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Heterostructure nanozyme-synergistically modulated electrochemiluminescence/photoelectrochemical sensing platform for detection of Alzheimer's disease biomarkers in plasma samples
In this work, a PtPd/CeO2 heterostructure nanozyme-synergistically modulated ternary ZnS/CdS/Bi2Se3 electrochemiluminescence/photoelectrochemical (ECL/PEC) aptasensor was designed for simultaneous detection of amyloid-β peptides (Aβ1-40 and Aβ1-42), as the key plasma biomarkers of Alzheimer's disease (AD). Benefiting…
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Ultrasensitive electrochemiluminescence aptasensor for Tau protein based on gold nanoparticle-modified perovskite nanocrystals
Early diagnosis for Alzheimer's disease (AD) is vital for effective therapeutic intervention and improved patient prognosis. In this work, we developed a highly sensitive electrochemiluminescence (ECL) aptasensor for detecting a key AD biomarker, Tau protein. An all-inorganic perovskite CsPbBr3 nanocrystals (NCs) were…
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Multicompartment Drug Monitoring Reveals Paired Brain-Liver Kinetics and Selective Central Nervous System Barrier Permeability in Rats
Characterizing drug distribution to target organs is of central importance to drug discovery, especially for compounds intended to reach the central nervous system (CNS). However, the current benchmark standard measurements, based on tissue homogenate, provide limited spatial and temporal resolution. Here, we use…
- An electrochemiluminescence aptasensor based on resonance energy transfer between MXene/prussian blue analog hollow spheres and MXene@ZIF-67 for sensitive detection of Alzheimer's disease biomarkers
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Circular RNA in human brain: Systematic review of synaptic functions and disease associations
Circular RNAs (circRNAs) are covalently closed, non-canonical transcripts, highly enriched in the mammalian brain and especially synaptic compartments. Generated via back-splicing of precursor mRNAs, their intrinsic stability and spatiotemporally regulated expression enable the modulating function for synaptic…
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Determination of Small-Sized α-Synuclein Oligomers Using Solid-State Nanopore Assisted with Circular Single-Stranded DNA Frame
Misfolded α-synuclein (αS) is significantly associated with the onset and progression of Parkinson's disease (PD), a critical neurodegenerative disorder. In particular, small-sized aggregated αS oligomers are more cytotoxic than mature amyloid-type aggregates and are essential inducers of PD. Solid-state nanopores,…
How this list is built · 这份榜单怎么来的
Sources. PubMed, OpenAlex and bioRxiv are polled daily for aptamer-related publications; records are de-duplicated by DOI.
Topic filter. A paper enters this list when its title or abstract matches any of: Alzheimer*, Parkinson*, amyloid, tau protein, Huntington*, amyotrophic, neurodegenerat*, prion, synuclein, neurofibrillar*, dementia, CNS (SQLite FTS5, case-insensitive, * is a prefix wildcard). A paper can belong to several topics.
Ranking. composite = 0.45×log(IF) + 0.35×log(citation velocity) + 0.10×social + 0.10×recency, scaled to 100. Citation velocity is citations per day since publication, so a recent paper accruing citations quickly can outrank an older one with a larger total. The recency term decays linearly to zero at 30 days, so anything older than a month is ranked on impact and citation velocity alone — this list therefore tilts towards recent work by design.
What this is not. The ranking is computed from metadata — journal impact factor, citation counts, recency — not from reading the papers. It is a triage aid for deciding what to read, not a quality judgement or a substitute for a systematic review. Impact factor is missing for some venues (preprints in particular) and those papers score lower than their content may deserve.
这份榜单由元数据算出——期刊影响因子、引用数、时效性——而不是通过阅读论文得到。它是决定「先读哪篇」的分诊工具，不是质量判断，也不能替代系统综述。部分来源（尤其预印本）没有影响因子，其得分会低于内容应得的水平。
Where these papers appear · 语料期刊分布
| Journal | Papers | IF |
|---|---|---|
| Biosensors & bioelectronics | 5 | 10.7 |
| Talanta | 5 | 6.1 |
| bioRxiv (Cold Spring Harbor Laboratory) | 4 | — |
| Zenodo (CERN European Organization for Nuclear Research) | 4 | — |
| Advanced Science | 2 | 14.3 |
| International journal of biological macromolecules | 2 | 7.7 |
| Analytical chemistry | 2 | 6.7 |
| Microchemical Journal | 2 | 4.9 |
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