Top aptamer papers on therapeutics — updated daily

Highest-scoring papers · 高分论文

1. Folic acid-anchored liposomes in cancer therapy: a next-generation nanoplatform for precision drug delivery and tumor targeting

   Journal of biomaterials science. Polymer edition · 2026-09-01 · 2 citations · score 15.5

   Targeted drug delivery (TDD) has emerged as a potential strategy for cancer management by selectively delivering therapeutic agents directly to the targeted site. The current trends in TDD for cancer therapy, focus on the use of various ligands, such as hyaluronic acid, folic acid (FA), carbohydrates, peptides,…

2. SOLiD-MaP: A Photoproximity Labeling Platform for Small Molecule Binding Site Mapping on RNA

   Angewandte Chemie (International ed. in English) · IF 16.1 · 2026-09-07 · 0 citations · score 14.9

   RNA-targeting small molecules are emerging as promising therapeutic modalities, but their development requires methods that define binding sites and evaluate RNA target selectivity. Existing approaches for detecting ligand-RNA interactions have provided powerful foundations, yet many rely on direct cross-linking or…

3. Mammalian therapeutic riboswitches: Engineering and custom ligands

   Molecular therapy. Nucleic acids · IF 8.8 · 2026-09-08 · 0 citations · score 14.1

   Regulation with riboswitches, which induce or repress gene expression in response to a ligand, is moving from proof-of-concept studies to robust clinical-grade gene therapies. These initial stages in RNA-based precision medicine will soon benefit from the next generation of riboswitches, whose engineering results from…

4. Small-Molecule-Directed RNA Modification via Proximity-Driven Catalysis

   Journal of the American Chemical Society · IF 14.4 · 2026-09-02 · 0 citations · score 13.0

   Selective chemical modification of RNA is essential for RNA functionalization, probing RNA structure-function relationships and developing RNA-targeted therapeutics. Existing chemical strategies often rely on guanine accessibility or multiple helper DNA strands, restricting their generality and biological…

5. Multivariate-Activated DNA Logic Gate for Predicting Responses to Cisplatin-Based Chemotherapy

   Analytical Chemistry · IF 6.7 · 2026-09-06 · 0 citations · score 13.0

   Abstract Cisplatin-based chemotherapy remains an attractive alternative for controlling advanced cancers. However, a subset of cancer patients exhibits resistance to cisplatin. Accurate and early prediction of individual responses to cisplatin treatment is critical to personalized medicine guidance. The development of…

6. Co-Assembled Mirror-Image DNA Nanostructure for Effective Alleviation of Acute Kidney Injury

   Angewandte Chemie (International ed. in English) · IF 16.1 · 2026-09-01 · 0 citations · score 12.9

   The high demand for acute kidney injury (AKI) therapy calls for the development of new therapeutics for renal management. Oxidative stress, coupled with excessive inflammation, is the main pathological mechanism for AKI. Specifically, complement component 5a (C5a) exacerbates the vicious cycle between oxidative stress…

7. Competitive SELEX Strategy for High-Affinity Aptamer Isolation and Enhanced Biosensing

   Small (Weinheim an der Bergstrasse, Germany) · IF 13.0 · 2026-09-02 · 0 citations · score 12.8

   Aptamers, with their high specificity and affinity, are invaluable for diagnostics and therapeutics. However, conventional SELEX (Systematic Evolution of Ligands by Exponential Enrichment) often favors abundant low-affinity sequences, limiting the isolation of rare, high-affinity candidates. To overcome this…

8. Aptamer-Functionalized Liposomes for Targeted Delivery of Anticancer Drugs in Lung Cancer

   Molecules · IF 4.2 · 2026-09-07 · 0 citations · score 12.6

   Aptamer-functionalized liposomes are a promising strategy to improve the selectivity of anticancer therapies. AT11-L2 is a G-quadruplex (G4)-forming aptamer with high affinity for nucleolin (NCL), which is overexpressed at the surface of non-small cell lung cancer (NSCLC) cells. Here, we developed…

9. T cell-anchored ATP-responsive doxorubicin-loaded dual aptamer DNA nanodevice for enhanced solid tumor therapy

   Chemical Engineering Journal · IF 13.4 · 2026-09-01 · 0 citations · score 12.6

10. A Receptor-Mediated Endolysosomal Recycling Chimera Enables Catalytic TNF-α Degradation for Sustained Treatment of Mucosal Inflammation

    Advanced materials (Deerfield Beach, Fla.) · IF 27.4 · 2026-08-28 · 0 citations · score 12.5

    Mucosal inflammatory disorders such as dry eye disease (DED) and inflammatory bowel disease (IBD), driven by TNF-α-mediated immune-epithelial crosstalk, remain therapeutically challenging. Conventional inhibitors often suffer from poor mucosal permeability and transient efficacy with 1:1 binding. Although…

11. Multi-Technique Integration Identifies O-GlcNAc Transferase in Fibroblast-Like Synoviocytes as a Therapeutic Target for Rheumatoid Arthritis

    Advanced science (Weinheim, Baden-Wurttemberg, Germany) · IF 14.3 · 2026-08-31 · 0 citations · score 12.3

    Rheumatoid arthritis (RA) progression is driven by the pathogenic transformation of stromal fibroblast-like synoviocytes (FLSs). Using artificial intelligence-guided analysis of a synovial single-cell transcriptomic dataset, we identify O-GlcNAc transferase (OGT) as a key regulator enriched in RA-FLSs. Gain- and…

12. Sensitive Detection of Biomarker Using Multifunctional Aptamer-Modified Fluorescent E. coli O157:H7

    Analytical Chemistry · IF 6.7 · 2026-09-04 · 0 citations · score 12.3

    Abstract Highly sensitive quantification of biomarkers is essential for disease diagnosis, treatment monitoring, and prognosis evaluation. Recently, nanomaterial-based immunosensors have attracted increasing attention due to their high sensitivity. However, the preparation of nanomaterials is often complex, costly,…

13. Double-target responsive FRET sensor based on DNA tetrahedron for robust detection of liver fibrosis-related mRNAs in activated hepatic stellate cells

    Biosensors & bioelectronics · IF 10.7 · 2026-09-01 · 0 citations · score 12.1

    Early diagnosis and graded evaluation of liver fibrosis remained challenging due to the limited sensitivity and accuracy of current noninvasive diagnostic tools. The imaging strategy of intracellular disease-related biomarker based on DNA nanoparticles had been used for accurate diagnosis and prognosis studies.…

14. An Au NC- and Ag NP-Loaded DNA Microcapsule-Based System for the Detection and Elimination of Staphylococcus aureus

    Analytical chemistry · IF 6.7 · 2026-09-01 · 0 citations · score 11.3

    Early detection and deactivation of Staphylococcus aureus (S. aureus) are of great importance to prevent pathogen-induced bacterial infectious diseases. Here, we initially synthesized stimuli-responsive DNA microcapsule coencapsulating gold nanoclusters (Au NCs) and silver nanoparticles (Ag NPs) (Au/Ag/DNA…

15. Programmable Electrochemical Cefapirin Antibiotic Aptasensor Powered by Highly Conductive Bimetallic NiCu(HITP) MOF and Dendritic DNA Amplifications

    Analytical chemistry · IF 6.7 · 2026-09-01 · 0 citations · score 11.3

    Residues of veterinary antibiotics in animal-derived foods motivate the development of analytical methods that combine high sensitivity with straightforward operation. Cefapirin, a β-lactam used extensively for the treatment of bovine mastitis, may persist in milk and other commodities; therefore, sensitive detection…

16. CHAI-sEV: A Programmable Hairpin-Driven Cas9 Platform with AI Integration for Dual-Protein Profiling and Intelligent Classification of Tumor-Derived Small Extracellular Vesicles

    Analytical Chemistry · IF 6.7 · 2026-09-01 · 0 citations · score 11.3

    Abstract Multiplexed protein profiling of tumor-derived small extracellular vesicles (TsEVs) requires signal-conversion strategies that are sensitive, low-background, and orthogonal. Collateral-cleavage CRISPR assays based on Cas12a or Cas13a provide efficient amplification but can compromise single-pot multitarget…

17. Conducting Polymer–Nanomaterial Hybrids for Cancer Diagnostics

    Biosensors · IF 5.4 · 2026-09-01 · 0 citations · score 11.0

    Cancer continues to pose a major global burden because of the high incidence and mortality, underscoring the urgent need for innovative and highly sensitive diagnostic technologies. Conducting polymer–nanomaterial (CP–NM) hybrid biosensors have become promising platforms for cancer biomarker detection, integrating the…

18. Oxygen vacancies-induced dual-interface modulation for TiO(2)/BiOI-based photoelectrochemical biosensor of urinary cancer markers

    Biosensors & bioelectronics · IF 10.7 · 2026-08-28 · 0 citations · score 10.8

    Non-invasive urine-based cancer biomarker detection holds significant clinical value in cancer screening, treatment efficacy monitoring, recurrence warning, and auxiliary diagnosis. To address the issues of poor sensitivity and selectivity in photoelectrochemical (PEC) biosensing for the detection of cancer biomarkers…

19. The Graphene Oxide-Anchored Releasable Aptamer Scaffold (GRAS) Technique Enables Efficient Exosome Capture and Controllable Release

    ACS applied bio materials · IF 4.7 · 2026-09-01 · 0 citations · score 10.7

    Exosomes, as key mediators of intercellular communication, exhibit promising prospects in the biomedical field, particularly in stem cell-based replacement therapy. Current exosome isolation techniques face challenges in achieving batch enrichment and nondestructive release, which severely restrict their applications.…

20. A Differential Electrochemical Sensor for Resolving Metabolite Cross-Reactivity Toward Selective Chemotherapy Monitoring

    ACS sensors · IF 8.2 · 2026-08-28 · 0 citations · score 10.3

    Despite its widespread use, high-dose methotrexate (MTX) regimen presents a risk of life-threatening nephrotoxicity. Consequently, rigorous monitoring of MTX levels at predefined time points is highly recommended to assess toxicity and guide dosing of rescue therapy such as glucarpidase. Upon administration,…