Aptamer 学术简报 — therapeutic — 2026-09-07

自动生成 by RBTX Aptamer Tracker v0.1。 子主题 therapeutic：近 14 天 66 篇命中（aptamer 池 232 篇）。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [13.7] Small-Molecule-Directed RNA Modification via Proximity-Driven Catalysis.

Selective chemical modification of RNA is essential for RNA functionalization, probing RNA structure-function relationships and developing RNA-targeted therapeutics. Existing chemical strategies often rely on guanine accessibility or multiple helper DNA strands, restricting their generality and biological applicability. Inspired by DNA-guided DM...

#2 [13.6] Co-Assembled Mirror-Image DNA Nanostructure for Effective Alleviation of Acute Kidney Injury.

The high demand for acute kidney injury (AKI) therapy calls for the development of new therapeutics for renal management. Oxidative stress, coupled with excessive inflammation, is the main pathological mechanism for AKI. Specifically, complement component 5a (C5a) exacerbates the vicious cycle between oxidative stress and inflammatory responses....

#3 [13.5] Competitive SELEX Strategy for High-Affinity Aptamer Isolation and Enhanced Biosensing.

Aptamers, with their high specificity and affinity, are invaluable for diagnostics and therapeutics. However, conventional SELEX (Systematic Evolution of Ligands by Exponential Enrichment) often favors abundant low-affinity sequences, limiting the isolation of rare, high-affinity candidates. To overcome this challenge, we introduce a competitive...

#4 [13.2] A Receptor-Mediated Endolysosomal Recycling Chimera Enables Catalytic TNF-α Degradation for Sustained Treatment of Mucosal Inflammation.

Mucosal inflammatory disorders such as dry eye disease (DED) and inflammatory bowel disease (IBD), driven by TNF-α-mediated immune-epithelial crosstalk, remain therapeutically challenging. Conventional inhibitors often suffer from poor mucosal permeability and transient efficacy with 1:1 binding. Although extracellular protein degradation (eTPD)...

#5 [13.0] Multi-Technique Integration Identifies O-GlcNAc Transferase in Fibroblast-Like Synoviocytes as a Therapeutic Target for Rheumatoid Arthritis.

Rheumatoid arthritis (RA) progression is driven by the pathogenic transformation of stromal fibroblast-like synoviocytes (FLSs). Using artificial intelligence-guided analysis of a synovial single-cell transcriptomic dataset, we identify O-GlcNAc transferase (OGT) as a key regulator enriched in RA-FLSs. Gain- and loss-of-function studies demonstr...

#6 [13.0] Sensitive Detection of Biomarker Using Multifunctional Aptamer-Modified Fluorescent E. coli O157:H7

Abstract Highly sensitive quantification of biomarkers is essential for disease diagnosis, treatment monitoring, and prognosis evaluation. Recently, nanomaterial-based immunosensors have attracted increasing attention due to their high sensitivity. However, the preparation of nanomaterials is often complex, costly, and environmentally unfriendly...

#7 [12.8] Double-target responsive FRET sensor based on DNA tetrahedron for robust detection of liver fibrosis-related mRNAs in activated hepatic stellate cells.

Early diagnosis and graded evaluation of liver fibrosis remained challenging due to the limited sensitivity and accuracy of current noninvasive diagnostic tools. The imaging strategy of intracellular disease-related biomarker based on DNA nanoparticles had been used for accurate diagnosis and prognosis studies. However, their sensitivity and acc...

#8 [12.0] An Au NC- and Ag NP-Loaded DNA Microcapsule-Based System for the Detection and Elimination of Staphylococcus aureus.

Early detection and deactivation of Staphylococcus aureus (S. aureus) are of great importance to prevent pathogen-induced bacterial infectious diseases. Here, we initially synthesized stimuli-responsive DNA microcapsule coencapsulating gold nanoclusters (Au NCs) and silver nanoparticles (Ag NPs) (Au/Ag/DNA microcapsule) and, using it, developed ...

#9 [12.0] Programmable Electrochemical Cefapirin Antibiotic Aptasensor Powered by Highly Conductive Bimetallic NiCu(HITP) MOF and Dendritic DNA Amplifications.

Residues of veterinary antibiotics in animal-derived foods motivate the development of analytical methods that combine high sensitivity with straightforward operation. Cefapirin, a β-lactam used extensively for the treatment of bovine mastitis, may persist in milk and other commodities; therefore, sensitive detection of trace-level cefapirin res...

#10 [12.0] CHAI-sEV: A Programmable Hairpin-Driven Cas9 Platform with AI Integration for Dual-Protein Profiling and Intelligent Classification of Tumor-Derived Small Extracellular Vesicles

Abstract Multiplexed protein profiling of tumor-derived small extracellular vesicles (TsEVs) requires signal-conversion strategies that are sensitive, low-background, and orthogonal. Collateral-cleavage CRISPR assays based on Cas12a or Cas13a provide efficient amplification but can compromise single-pot multitarget detection, whereas the sequenc...

Methodology