Aptamer 学术简报 — infectious_disease — 2026-09-09

自动生成 by RBTX Aptamer Tracker v0.1。 子主题 infectious_disease：近 14 天 9 篇命中（aptamer 池 228 篇）。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [12.9] An interface-engineered signal-on electrochemical aptasensor for H5N2 avian influenza virus detection.

Outbreaks of avian influenza virus (AIV) cause substantial economic losses in the poultry industry, highlighting the need for sensitive, reliable and field-adaptable detection platforms. In this study, we report a signal-on electrochemical aptasensor for avian influenza virus H5N2(K08-404) by translating a previously reported J3/JH4 cognate apta...

#2 [10.3] A Rationally Designed Split Lettuce Aptamer Based on Large-Scale Mutational Analysis.

Split-aptamer biosensors offer exceptionally low background by assembling only in the presence of a target analyte; however, their performance is frequently limited by the lack of robust design rules for selecting effective split sites. Existing approaches largely rely on heuristic, structure-based assumptions that are poorly validated and often...

#3 [9.3] Multifunctional CMC–Nanographene Oxide Hydrogels Couple Fluorophore-Free Cancer Cell Imaging with Antioxidant and Antimicrobial Activity

Background: The development of sustainable biomaterials that combine imaging capability with complementary biological functions without relying on incorporated drugs or exogenous fluorophores represents an attractive strategy for multifunctional biomedical platforms. Methods: Here, carboxymethyl cellulose (CMC) hydrogels reinforced with nanograp...

#4 [8.7] DNA aptamers to interfere with HasA, the hemophore of the heme assimilation system in Pseudomonas aeruginosa, as a potential antimicrobial strategy

Pseudomonas aeruginosa relies on heme acquisition to sustain growth and virulence in the iron-limited environment of the host, particularly in the acidic airways of patients with cystic fibrosis where antibiotic efficacy is markedly reduced. The Has heme assimilation system is initiated by the secreted hemophore HasA, which binds extracellular h...

#5 [8.0] Identification of a SARS-CoV-2 Spike RNA-Cleaving DNAzyme and Optimization of Its AS1411 Chimera

Sequence-specific cleavage of viral RNA by deoxyribozymes offers a direct approach for suppressing viral gene expression, although limited cellular accessibility remains a major barrier to their functional application. In this study, a panel of eight deoxyribozymes representing different catalytic motifs and target regions was designed against S...

#6 [7.3] Target, silence, replace: a review on RNA-based drugs in modern medicine

RNA therapies have evolved into a revolutionary approach in contemporary medicine for treating various diseases by directly targeting RNA molecules engaged in disease pathogenesis. These therapeutic agents regulate biological processes through diverse mechanisms, including modulation of RNA function and gene expression. Medical applications of R...

#7 [7.0] Advancing Tuberculosis Antigen Detection by Selecting Sandwich-Compatible Aptamers Against the Mycobacterium tuberculosis ESAT-6/CFP-10 Heterodimer Using Library-Immobilized Strategies

Abstract Tuberculosis (TB) represents the world’s leading infectious disease killer, surpassing COVID-19. Despite being preventable and curable, a substantial proportion of cases remain undiagnosed or unreported, sustaining transmission. The detection of antigens such as the Mycobacterium tuberculosis ESAT-6/CFP-10 heterodimer, which are secrete...

#8 [6.0] From host response to genomic targets: electrochemical biosensing of tuberculosis biomarkers.

Tuberculosis (TB) remains one of the leading causes of death from a single infectious agent worldwide, with timely diagnosis continuing to be a major challenge, particularly in resource-limited settings. Conventional TB diagnostic methods are limited by low sensitivity, long turnaround times, and an inability to reliably differentiate latent fro...

Methodology