Aptamer 学术简报 — infectious_disease — 2026-08-28

自动生成 by RBTX Aptamer Tracker v0.1。 子主题 infectious_disease：近 14 天 9 篇命中（aptamer 池 192 篇）。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [11.2] High-ThroughputOn-Chip Screening Enables Rapid Adaptationof DNA Aptamers to SARS-CoV-2 Evolution

Abstract Rapid pathogen evolution threatens public health by eroding the effectiveness of vaccines, therapeutics, and diagnostic tools. Although spike-protein-targeting monoclonal antibodies (mAbs) were developed within 10–12 months of the initial outbreak to serve as key theranostic agents, their redesign has struggled to keep pace with viral e...

#2 [11.2] Chimeric ascorbic acid phosphate-releasing nucleotide probes for isothermal signal-amplified protein detection.

Protein detection is essential for disease diagnosis and biomarker analysis but often relies on antibodies and sophisticated instrumentation. Here, we report a signal-amplified protein detection strategy based on chimeric ascorbic acid-2-phosphate (AAP)-releasing nucleotide probes and strand displacement amplification (SDA). Two tetraphosphate n...

#3 [10.5] Surface-confined CRISPR-Cas12a biosensor with metal-enhanced fluorescence for rapid and ultrasensitive detection of SARS-CoV-2 nucleocapsid protein.

CRISPR-Cas12a integrated with nanomaterials has formulated powerful biosensors for viral protein detection, addressing the urgent need for point-of-care diagnostics. However, existing platforms are hindered by either multi-step separation procedures or insufficient signal amplification, limiting their sensitivity and practicality. Here, we repor...

#4 [9.7] Single-Particle Tracking and Positional Phenotyping Reveal Variant-Specific Early Checkpoints in SARS-CoV-2 Cell Entry.

Bulk assays of SARS-CoV-2 entry obscure individual virions and conflate binding with internalization. We developed a quantitative single-particle imaging assay that classifies fluorescent virus-like particles (VLPs) as surface, crossing, or internal on HEK293T-ACE2 cells, separating binding from internalization. Comparing G614 and Omicron BA.5 S...

#5 [7.0] High-Sensitivity Magnetic Particle Spectroscopy Platform for Precise, Specific, and Rapid Detection of Infectious Disease and Cancer-Related Biomarkers.

Accurate biosensing using magnetic particle spectroscopy (MPS) depends on the interplay between biomolecular binding and the fidelity of the measurement system. MPS enables wash-free, label-free biosensing by monitoring Brownian relaxation-induced changes in magnetic nanoparticle (MNP) dynamics. However, its practical performance is often limite...

#6 [6.3] A label-free and highly sensitive fluorescence aptasensor for enrofloxacin detection based on G-triplex-mediated signal amplification.

Enrofloxacin (ENR), a third-generation fluoroquinolone veterinary antibiotic, is widely used in aquaculture and animal husbandry for bacterial infection control due to its broad-spectrum antimicrobial activity, potent bactericidal efficacy, and cost-effectiveness. However, its excessive and non-standard use has caused widespread residues in anim...

Methodology