Aptamer 学术简报 — cancer — 2026-08-31

自动生成 by RBTX Aptamer Tracker v0.1。 子主题 cancer：近 14 天 44 篇命中（aptamer 池 182 篇）。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [13.0] A Cascaded DNA Nanocircuit for Multi‐Signal‐Responsive Precision siRNA Delivery in Cancer Therapy

Precision control over nucleic acid delivery remains a critical challenge in cancer therapy, particularly for siRNA-based gene silencing, where off-target effects limit clinical translation. Herein, we report a programmably engineered DNA nanocircuit with cascaded dual-AND logic gates, which enables the development of a spatiotemporally controll...

#2 [12.9] Application of aptamer nucleic acid test strips in the detection of tumor markers for colorectal cancer.

At present, the detection methods of tumor markers rely on ELISA, gene sequencing, and other technologies. However, these methods require specialized equipment and technical personnel, and the low concentrations of early tumor markers limit their sensitivity. This study developed a method for detecting colorectal cancer tumour markers. It uses a...

#3 [12.8] Aptamer-functionalized terahertz metasensor for sensitive and specific determination of alpha-fetoprotein.

Alpha-fetoprotein (AFP) is a key serum biomarker for the early diagnosis of hepatocellular carcinoma (HCC). In this study, a dual-band terahertz (THz) metasurface sensor (metasensor) was developed and functionalized with computationally selected aptamers for sensitive and specific detection of AFP. A 1000-sequence ssDNA library was screened usin...

#4 [12.1] Cascade-coupled colorimetric-fluorescent dual-signal detection of EGFR-positive extracellular vesicles via bifunctional MOF@Pt nanozyme integrated with a CHA-CRISPR system.

Extracellular vesicle (EV)-based liquid biopsy holds great promise for glioma diagnosis, but its clinical translation remains hindered by inefficient isolation of disease-relevant EV subpopulations and insufficiently integrated signal validation. Herein, we develop a platform that integrates a bifunctional nanozyme system (phosphatase-like MOF a...

#5 [12.0] Advances in Extracellular Vesicle-Based Surface-Enhanced Raman Spectroscopy for Cancer Diagnosis

As a noninvasive liquid biopsy approach, extracellular vesicle (EV)-based detection offers significant advantages in reflecting real-time tumor dynamis and overcoming the limitations of conventional tissue biopsy. EVs, nanoscale vesicles secreted by cells, carry diverse biomolecules such as proteins and nucleic acids, playing key roles in tumor ...

#6 [11.9] Antibodies and aptamers as affinity ligands for exosome isolation, detection, and targeted delivery: A review.

Exosomes, key mediators of intercellular communication, are emerging as promising tools for disease diagnosis and therapy. Realizing this potential depends on technologies that can isolate, detect, and deliver exosomes with high specificity and efficiency. Affinity-based strategies that exploit the molecular recognition of antibodies and aptamer...

#7 [11.8] Enzyme-free dual-hotspot SERS immunosensor via cascaded boronate assembly

The precise detection of CA19-9 is paramount for early cancer diagnosis and clinical monitoring. However, traditional immunoassays are often hampered by their heavy reliance on matched antibody pairs and the insufficient sensitivity of enzymatic amplification systems. To address these limitations, we report a novel, enzyme-free surface-enhanced ...

#8 [11.7] An AuNF-modified optical fiber LSPR biosensor for sensitive and wide-range 5-HT detection.

Serotonin (5-hydroxytryptamine, 5-HT) is a critical biomarker for carcinoid tumor diagnosis, yet its precise quantification in clinical settings remains challenging. Herein, we develop a high-performance optical fiber localized surface plasmon resonance (LSPR) biosensor functionalized with in situ grown gold nanoflowers (AuNFs). The hierarchical...

#9 [11.3] Targeting Adaptive and Innate Immune Responses with Covalent Aptamers.

Covalent aptamers have recently found initial success as tools for fast and selective transfer of labels to target proteins. Here, aptamers targeting protein tyrosine kinase 7 (PTK7) and the mesenchymal-epithelial transition factor (cMet) were functionalized with electrophiles capable of covalently transferring small-molecule immune recruiters. ...

#10 [11.1] A bioelectronic interface for continuous neuroinflammation monitoring and neuromodulation in Parkinson's disease model.

Neuroinflammation is increasingly recognized as a critical driver in the onset and progression of Parkinson's disease (PD), yet technologies capable of continuously tracking neuroinflammatory dynamics in vivo remain limited. Here, we report an implantable bioelectronic interface that integrates multiplexed aptamer based electrochemical biosensin...

Methodology