Aptamer 学术简报 — cancer — 2026-07-08

自动生成 by RBTX Aptamer Tracker v0.1。 子主题 cancer：近 14 天 57 篇命中（aptamer 池 229 篇）。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [17.8] Multiplexed biosensing: A review of surface plasmon resonance platforms for biomarker analysis.

Surface plasmon resonance (SPR) has emerged as an important optical technology for the real-time, label-free analysis of biomolecular interactions. While its utility in detecting single analytes is well-established, the growing complexity of disease diagnostics demands tools capable of simultaneous multi-analyte detection. Many complex diseases,...

#2 [14.5] A Droplet-Microarray Platform for Multiplex Profiling of Breast Cancer Exosome Subtypes in Patients' Blood Plasma Samples.

Breast cancer is highly heterogeneous, with distinct subtypes-luminal A, HER2-positive, and triple-negative-each exhibiting unique behaviors and treatment responses. Accurate identification of these subtypes is essential for guiding personalized therapies and improving outcomes. Exosomes, small extracellular vesicles secreted by tumor cells, hav...

#3 [14.0] Next-generation electrochemical aptasensors for thrombin detection: the rise of aptamer-MOF architectures.

Thrombin is a crucial regulatory enzyme in the blood coagulation cascade that significantly influences cancer metastasis, cardiovascular disease, inflammation, and immunological regulation. Because of its dynamic, concentration-dependent activity, thrombin has emerged as a potential biomarker for the early diagnosis of a wide range of pathologic...

#4 [14.0] Self-assembled Nano-PROTACs: bridging chemical design and biological barriers in targeted protein degradation.

Self-assembled Nano-PROTACs represent an emerging class of programmable supramolecular degraders that integrate targeted protein degradation with nanoscale delivery to overcome the intrinsic limitations of conventional PROTACs. Conventional PROTACs are often constrained by poor solubility, limited membrane permeability, suboptimal pharmacokineti...

#5 [14.0] G-quadruplexes as therapeutic platforms for anticancer drug delivery: from intrinsic cytotoxicity to drug delivery and nanotechnology.

INTRODUCTION: G-quadruplexes have emerged as a versatile class of oligonucleotides that combine molecular recognition, intrinsic anticancer activity and drug carrier functions, offering new opportunities to improve tumor selectivity and overcome limitations of conventional chemotherapy. AREAS COVERED: This review summarizes structural and biolog...

#6 [13.9] High-Speed Atomic Force Microscopy Reveals Aptamer-Mediated Conformational Trapping of METTL3-METTL14 for m(6)A Inhibition.

The conformational dynamics of METTL3-METTL14 (M3/M14) heterodimer, the catalytic core for N6-methyladenosine (m6A) deposition, remain largely unexplored, limiting insight into dynamic regulation of catalysis and opportunities for therapeutic targeting in cancer. Here, we report the first single-molecule visualization of M3/M14 dynamics by high-...

#7 [13.8] In situ imaging of proximal biomolecules via Proximity Anchored Modules Assembly

Aberrant proximal biomolecular complexes are critical disease biomarkers. The precise in situ imaging of these complexes is essential for deciphering disease pathogenesis and precision diagnostics. However, current in situ analysis technologies are often constrained by limited resolution, diffusion-mediated false positives, or the requirements f...

#8 [13.6] Immunomagnetic hydrogel nanofibrils for exosomes isolation.

BACKGROUND: Exosomes (EXOs) are promising biomarker sources for liquid biopsy. Due to their low abundance in biofluids and the presence of non-target vesicle proteins during the isolation process, traditional methods such as ultracentrifugation (UC) are time-consuming, yield low purity, and can cause damage to EXOs. Achieving rapid, high-purity ...

#9 [13.6] Integrating DNA tetrahedron with affinity magnetic levitation for selective capture and sensitive detection of circulating tumor cells.

Circulating tumor cell (CTC) is an evidenced biomarker for early cancer diagnosis and assessment of treatment response. This necessitates increasing attempt to develop new method for detection of CTCs with highly enriching and anti-interference capacity. Herein, we built a simple platform for CTC detection by combining aptamer-mediated specific ...

#10 [13.5] Enzyme-enhanced albumin-stabilized nanopolymers for cascade catalysis-driven ferroptosis-immunotherapy

Ferroptosis, an iron-dependent form of programmed cell death, holds significant promise for cancer therapy due to its unique redox-driven mechanism and immunogenic potential. However, its therapeutic efficacy is often compromised by inadequate catalytic kinetics and an unfavorable tumor microenvironment. Here, we develop a multifunctional nanoca...

Methodology