Aptamer 学术简报 — cancer — 2026-07-01

自动生成 by RBTX Aptamer Tracker v0.1。 子主题 cancer：近 14 天 63 篇命中（aptamer 池 244 篇）。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [18.4] A photocurrent polarity switching photoelectrochemical aptasensor based on Er-MOF nanosheets and methylene blue for high-performance determination of CA15-3.

BACKGROUND: Photoelectrochemical (PEC) biosensors have attracted increasing interest for tumor biomarker detection due to their intrinsic advantages. However, conventional PEC sensing strategies are typically based on unidirectional "signal-on" or "signal-off" modes, which are vulnerable to matrix interferences in complex biological samples and ...

#2 [15.2] Spatially resolved profiling of extracellular vesicles in tissues with Spatial-EV-seq.

Extracellular vesicles (EVs) have emerged as promising biomarkers for monitoring physiological homeostasis and pathological progression. However, current analytic methods face limitations in preserving spatial information about EVs and their intricate connections to parental and recipient cells. Here, we present Spatial-EV-seq, a method for in s...

#3 [13.8] Biofilm surface proximity-induced branched hybridization chain reaction strategy based on microchip electrophoresis for distinguishing exosomes from different cancer cells.

The exosome surface contains various cancer markers that can be suitable candidates for early cancer diagnosis and therapeutic efficacy evaluation. However, due to the very small size of exosomes, major challenges remain to detect tumor markers on their surface. To circumvent these challenges, a signal amplification strategy based on microchip e...

#4 [13.8] Multiplexed biosensing: A review of surface plasmon resonance platforms for biomarker analysis.

Surface plasmon resonance (SPR) has emerged as an important optical technology for the real-time, label-free analysis of biomolecular interactions. While its utility in detecting single analytes is well-established, the growing complexity of disease diagnostics demands tools capable of simultaneous multi-analyte detection. Many complex diseases,...

#5 [13.7] Structural DNA Nanotechnology-Based Branch-Sprouted Biomimetic Nanobamboo for Efficient Isolation of Rare Circulating Tumor Cells.

Because of very few sequence-identified viral scaffolds suitable for origami assembly and the unavailability of tile-based, nondeformable, superlarge DNA structures with architecturally defined collective properties, the biomedical application of structural DNA nanotechnology is hampered. In the current contribution, we demonstrate a backbone-in...

#6 [13.5] Thermodynamic-Kinetic Tailored Photothermal-Responsive Molecular Switching for Extracellular Vesicle Manipulation.

Extracellular vesicles (EVs) are central mediators of intercellular communication and promising carriers for oncology diagnosis and therapeutic delivery, yet their isolation remains challenged by inadequate specificity, irreversible capture, and vesicle structural damage. Here, we present the Multifunctional Optically Regulated Plasmonic Heating...

#7 [13.5] 7-(Diethylamino)coumarin-3-carboxylic acid functionalized aptamers induced photoelectrochemical/fluorescence dual-mode microfluidic sensor for integrated detection of three liver cancer biomarkers.

Single-mode biosensor is prone to external interference, and detection of a single biomarker is insufficient for accurate diagnosis of liver cancer. Herein, we report a 7-(Diethylamino)coumarin-3-carboxylic acid (7DCCA) functionalized aptamers induced photoelectrochemical(PEC)/fluorescence(FL) dual-mode aptasensor integrated into a three-channel...

#8 [13.0] A FRET-Mediated AIE Biosensor Based on Functionalized Peptide-Stabilized Gold Nanoclusters for Sensitive Detection of Matrix Metalloproteinase-2

Matrix metalloproteinase-2 (MMP-2) represents a critical biomarker closely associated with tumor growth, invasion, and metastasis. Herein, we report an ultrasensitive biosensor that integrates Förster resonance energy transfer (FRET) and aggregation-induced emission (AIE) using functionalized peptide-stabilized gold nanoclusters (PG-Au NCs) and ...

#9 [12.9] Targeting delivery systems with aptamer-conjugated hyaluronic acid for personalized assessment of treatment response to targeted cancer therapy.

A central objective in oncology is to identify therapeutic targets essential for the survival of proliferating malignant cells. However, a major challenge in pre-clinical research is the scarcity of robust models capable of accurately assessing therapeutic efficacy in patient-specific heterogeneous cancer cells. Here, we developed an ex vivo pla...

#10 [12.3] Aptamer-Functionalized Liposome Delivery System Based on Multifunctional Microreactor Design.

Breast cancer remains the leading cause of cancer-related mortality in women, with conventional chemotherapy often limited by systemic toxicity due to poor drug targeting. Here, we present an integrated microfluidic chip (MMLP) that enables one-step integrated postprocessing, including solvent removal and ligand conjugation. The MMLP chip combin...

Methodology