Aptamer 学术简报 — 2026-07-03

自动生成 by RBTX Aptamer Tracker v0.1。 近 14 天入库 220 篇 aptamer-related papers。

评分公式：composite = 0.45×log(IF) + 0.35×log(cites_velocity) + 0.10×social + 0.10×recency_bonus；满分 100。

#1 [27.2] Magnetically induced aggregation-assisted mesoporous polydopamine/single-atom nanozyme platform for dual-channel detection and two-stage synergistic eradication of pathogens.

Contamination with foodborne pathogenic bacteria poses a severe threat to public health, necessitating the integration of detection with source sterilization technologies. Herein, we developed an integrated nanoplatform by combining an aptamer-modified mesoporous polydopamine/palladium single-atom carbon dot composite probe (MPDA/Pd SA@DA-CDs/Ap...

#2 [27.2] High affinity and selective DNA aptamers for the detection of tobramycin in eye drops.

Tobramycin is a frontline aminoglycoside antibiotic with a narrow therapeutic window. Here, we report the selection of high-affinity DNA aptamers using a library-immobilization based SELEX strategy. The lead aptamer, TOB-2, binds tobramycin with a dissociation constant of 420 nM as determined by isothermal titration calorimetry, while exhibiting...

#3 [23.7] Microscale thermophoresis sensor for homogeneous and one-step protein detection based on dual aptamers binding induced DNA switch.

Rapid and sensitive detection of proteins is in great demand in disease diagnostics, drug discovery, basic research, and other biomedical applications. The emerging microscale thermophoresis (MST) technique, which enables to monitor fluorescence responses of fluorescent molecules under heating in real time, provides an attractive avenue for sens...

#4 [23.7] Multiplexed biosensing: A review of surface plasmon resonance platforms for biomarker analysis.

Surface plasmon resonance (SPR) has emerged as an important optical technology for the real-time, label-free analysis of biomolecular interactions. While its utility in detecting single analytes is well-established, the growing complexity of disease diagnostics demands tools capable of simultaneous multi-analyte detection. Many complex diseases,...

#5 [22.6] AI-driven Cu/Mn-CeO(2) nanozyme-functionalized paper-based biosensor for quantitative monitoring of alternariol in food.

The lack of rapid, user-friendly methods for alternariol (AOH), a prevalent emerging mycotoxin, presents a considerable analytical challenge. This work introduces an integrated sensing strategy advancing from classical homogeneous liquid-phase detection to a portable AI-enhanced paper-based biosensor. The system employed a Cu/Mn-CeO2 nanozyme as...

#6 [19.9] Next-generation electrochemical aptasensors for thrombin detection: the rise of aptamer-MOF architectures.

Thrombin is a crucial regulatory enzyme in the blood coagulation cascade that significantly influences cancer metastasis, cardiovascular disease, inflammation, and immunological regulation. Because of its dynamic, concentration-dependent activity, thrombin has emerged as a potential biomarker for the early diagnosis of a wide range of pathologic...

#7 [19.9] Self-assembled Nano-PROTACs: bridging chemical design and biological barriers in targeted protein degradation.

Self-assembled Nano-PROTACs represent an emerging class of programmable supramolecular degraders that integrate targeted protein degradation with nanoscale delivery to overcome the intrinsic limitations of conventional PROTACs. Conventional PROTACs are often constrained by poor solubility, limited membrane permeability, suboptimal pharmacokineti...

#8 [19.9] G-quadruplexes as therapeutic platforms for anticancer drug delivery: from intrinsic cytotoxicity to drug delivery and nanotechnology.

INTRODUCTION: G-quadruplexes have emerged as a versatile class of oligonucleotides that combine molecular recognition, intrinsic anticancer activity and drug carrier functions, offering new opportunities to improve tumor selectivity and overcome limitations of conventional chemotherapy. AREAS COVERED: This review summarizes structural and biolog...

#9 [19.9] Plasma proteomic profiles of lung volume-based phenotypes in tobacco-exposed individuals without spirometric chronic obstructive pulmonary disease.

BACKGROUND: Among individuals with a history of smoking but preserved spirometry (tobacco exposed with preserved spirometry, or TEPS), lung volume-based stratification identifies 2 phenotypes at increased risk for chronic obstructive pulmonary disease (pre-COPD): those with a relatively elevated total lung capacity ([TLC]high) and those with a r...

#10 [18.3] Ultrasensitive, Real-Time Molecular Sensing in Unprocessed Whole Blood Using Surface-Enhanced Raman Scattering Combined with Glycocalyx-Mimicking Structures.

Rapid, real-time, and ultrasensitive molecular sensing in unprocessed whole blood remains a major challenge due to biofouling, narrow dynamic ranges, and the need for rapid equilibration. We report a biomimetic surface-enhanced Raman scattering (SERS) platform that integrates structure-switching aptamers with a self-assembling, lubricin (proteog...

Methodology